The P0306 trouble code on your 2022 Lexus ES indicates that the engine control module has detected a misfire on cylinder 6. The 2022 ES350 is powered by a 3.5L V6 engine (2GR-FKS) producing 302 horsepower, so this code is completely valid for your vehicle.
Understanding the ES350's V6 Engine
The 2022 ES350 uses Toyota/Lexus's refined 3.5L V6 with the D-4S dual injection system, combining port and direct fuel injection for optimal combustion. Cylinder 6 is located at the rear of the right (passenger) bank in the transverse-mounted engine.
Common Causes of P0306
- Ignition Coil Failure: The coil-on-plug design can fail without warning
- Worn Spark Plugs: Iridium plugs require replacement at specified intervals
- Direct Fuel Injector Issues: Carbon buildup or mechanical failure
- Intake Valve Carbon Deposits: Common in direct injection engines
- Vacuum Leaks: Intake manifold or gasket leaks near cylinder 6
- Low Compression: Valve or piston ring wear
Diagnosis Tips for Lexus Owners
The ES350's engine bay provides reasonable access to components, though the rear cylinders require more effort to reach. Begin with non-invasive testing using scan data before removing components. The ignition coils can be swapped between cylinders to isolate coil versus spark plug issues.