A P0303 diagnostic code on your 2022 Lexus ES indicates the engine control module has detected repeated misfires in cylinder 3. The luxury sedan offers both V6 and hybrid powertrains with specific diagnostic considerations.
2022 ES Powertrain Options
The 2022 ES 350 uses the 2GR-FKS 3.5L V6 with D-4S dual injection. The ES 300h uses a 2.5L inline-4 with hybrid assistance. On the V6, cylinder 3 is at the rear of the left bank. On the inline-4, cylinder 3 is third from the front.
Common Causes
- Ignition Coil Failure: Both engines use coil-on-plug ignition
- Spark Plug Wear: Long-life iridium plugs eventually need service
- Fuel Injector Issues: D-4S V6 has dual injectors; hybrid has port injection
- Carbon Buildup: V6's direct injection can cause valve deposits
- Intake Manifold Leaks: Gasket or vacuum line failures
Diagnostic Approach
Identify your engine type first. Use Lexus-compatible diagnostics for detailed access. Monitor misfire counts and fuel trim data. Test ignition components systematically before moving to mechanical causes.
Repair Solutions
Replace failed ignition coils with Denso OEM-equivalent parts. Install Lexus-specified iridium spark plugs. Address fuel injector issues through cleaning or replacement. Consider carbon cleaning for higher mileage V6 models.