A P0302 code on your 2022 Mercedes-Benz E-Class indicates the engine control module has detected misfires in cylinder 2. The W213 E-Class offers the M264 2.0L turbo four-cylinder in E350 or the M256 3.0L turbo inline-6 in E450 models. Each engine has specific diagnostic considerations.
W213 Engine Options
The E350 uses the M264 2.0L turbo producing 255 horsepower. The E450 features the M256 3.0L turbo inline-6 producing 362 horsepower with EQ Boost mild hybrid. Both inline engines position cylinder 2 second from the timing end.
Common Misfire Causes
Direct injection carbon buildup can develop on intake valves over time. Ignition coil degradation from turbo heat affects spark delivery. Spark plug wear reduces ignition energy. High-pressure fuel system issues can cause misfires. Boost irregularities affect combustion.
Symptom Recognition
Both engines display rough idle, vibration, and hesitation with misfires. The six-cylinder may mask symptoms slightly due to additional cylinders. The executive sedan's refined character suffers. Check engine light accompanies the condition.
Diagnostic and Repair Approach
Identify engine type. Use Mercedes-Benz compatible diagnostics. Inspect ignition components on cylinder 2. Test fuel system. Verify boost pressure. Given the newer model year, warranty coverage should apply to defect-related issues.